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ixabepilone  (Bristol Myers)

 
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    Structured Review

    Bristol Myers ixabepilone
    (A) Design strategy for <t>ixabepilone</t> based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).
    Ixabepilone, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ixabepilone/product/Bristol Myers
    Average 90 stars, based on 1 article reviews
    ixabepilone - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Unraveling the therapeutic landscape of approved non-peptide macrocycles"

    Article Title: Unraveling the therapeutic landscape of approved non-peptide macrocycles

    Journal: Acta Pharmaceutica Sinica. B

    doi: 10.1016/j.apsb.2025.04.021

    (A) Design strategy for ixabepilone based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).
    Figure Legend Snippet: (A) Design strategy for ixabepilone based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).

    Techniques Used: Comparison, Binding Assay



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    (A) Design strategy for <t>ixabepilone</t> based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).
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    Image Search Results


    Structural response of microtubules to different ligand:tubulin ratios. The plots show the variation in average monomer length and protofilament number, highlighting the impact of ligand concentration on lattice organization. (A) paclitaxel, (B) docetaxel, (C) ixabepilone, (D) 3’aminobenzoyl paclitaxel, (E) zampanolide.

    Journal: bioRxiv

    Article Title: An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites

    doi: 10.1101/2025.11.11.687833

    Figure Lengend Snippet: Structural response of microtubules to different ligand:tubulin ratios. The plots show the variation in average monomer length and protofilament number, highlighting the impact of ligand concentration on lattice organization. (A) paclitaxel, (B) docetaxel, (C) ixabepilone, (D) 3’aminobenzoyl paclitaxel, (E) zampanolide.

    Article Snippet: Paclitaxel was from Alfa Aesar Chemical, docetaxel was kindly provided by Rhône Poulenc Rorer, Aventis (Schiltigheim, France), cabazitaxel and baccatin III were from Sigma, epothilones A, B, D, taccalonolide AJ and ixabepilone were from MedChemExpress; laulimalide and peloruside A were provided by Victoria University of Wellington; chitax 40, 101 y 102, 2-aminopaclitaxel, 3’N-aminopaclitaxel, flutax-1, flutax-2, Fchitax-3, 2-m-azido-baccatin III, hexaflutax, alatax, discodermolide, zampanolide, dactylolide, TB282, cyclostreptin, pelophen B and CW235 were synthesized as described ( , , , – ).

    Techniques: Concentration Assay

    Journal: bioRxiv

    Article Title: An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites

    doi: 10.1101/2025.11.11.687833

    Figure Lengend Snippet:

    Article Snippet: Paclitaxel was from Alfa Aesar Chemical, docetaxel was kindly provided by Rhône Poulenc Rorer, Aventis (Schiltigheim, France), cabazitaxel and baccatin III were from Sigma, epothilones A, B, D, taccalonolide AJ and ixabepilone were from MedChemExpress; laulimalide and peloruside A were provided by Victoria University of Wellington; chitax 40, 101 y 102, 2-aminopaclitaxel, 3’N-aminopaclitaxel, flutax-1, flutax-2, Fchitax-3, 2-m-azido-baccatin III, hexaflutax, alatax, discodermolide, zampanolide, dactylolide, TB282, cyclostreptin, pelophen B and CW235 were synthesized as described ( , , , – ).

    Techniques:

    (A) Design strategy for ixabepilone based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Unraveling the therapeutic landscape of approved non-peptide macrocycles

    doi: 10.1016/j.apsb.2025.04.021

    Figure Lengend Snippet: (A) Design strategy for ixabepilone based on epothilone B; (B) Comparison of the active site overlap between ixabepilone (PDB: 7DAF , shown in green) and epothilone B (PDB: 7DAE , shown in cyan) on Tubulin. (C) Analysis of the binding interaction between ixabepilone and Tubulin. Hydrogen bonds are highlighted in red dash lines. MDR (IC 50 R/S), the ratio of IC 50 values in MDR resistant versus sensitive cell lines. 3D visualizations were performed using PyMOL ( Pymol.org ).

    Article Snippet: Ixabepilone , Cancer , Tubulin , Bristol-Myers Squibb Co. , 2007 , FDA.

    Techniques: Comparison, Binding Assay